SagaPro

SagaPro

For bladder health
SagaPro is a clinically studied herbal supplement that reduces urinary frequency in people with low bladder capacity. It´s useful for many groups of people; namely those suffering from bladder problems like an overactive bladder (OAB), sometimes reffered to as "irritable bladder". SagaPro is a proprietary, aqueous extract of Angelica archangelica leaves, harvested from wild plants grown in the pure air and soil of Iceland. Wild Angelica is gathered by local people in an eco- friendly and sustainable manner.  SagaPro supports healthy bladder strength and function both for men and women.
 
Fast acting
* Only 1-2 tablets per day
* Results normally before 1 month
* Calms bladder muscle contraction
* Easy to measure by counting trips to the bathroom
* Improved sleep patterns
 
Clinical results
Participants in a recent clinical trial experienced support for healthy bladder function and reported improved sleep patterns as well.

SagaMedica's peer-reviewed studies

A peer-reviewed article was published in 2012 in The Scandinavian Journal of Urology and Nephrology.

Here you may find a selection of studies, which were performed by our research team and their colleagues. These studies have been published in respected scientific journals.

A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men.Significant results were found in subgroups, such as those with a small bladder capacity. Click here to view the clinical study on SagaPro.

Studies on essential oils of Icelandic Angelica archangelica seeds and Achillea millefolium. Their efficacy regarding the growth of cancer cells. Both cases showed great variability.

Findings regarding Angelica archangelica seeds have been published (along with findings regarding their activity on cancer cells) Considerable activity was found in the essential oils of Icelandic Angelica archangelica. These findings (along with findings regarding the chemical structure of the essential oils in question) have been published in: Sigurdsson S, Ogmundsdottir HM, and Gudbjarnason S (2005) The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L. Anticancer Res 25(3B): 1877-80

Studies on the activity of a tincture (extract with 45% ethanol) from seeds of the Icelandic Angelica archangelica on cancer cells.

Activity of furanocoumarins xanthotoxin and imperatorin was also studied. Findings revealed considerable activity in the tincture and with imperatorin and xanthotoxin (50% reduction in cancer cell proliferation was observed at 2,7 and 3,7 µg/ml). Comparative analysis indicated that activity in the tincture could be solely traced to furanocoumarins. These findings have been published in: Sigurdsson S, Ogmundsdottir HM, and Gudbjarnason S (2004) Antiproliferative effect of Angelica archangelica fruits. Z Naturforsch 59c(7-8):523-7

Research into the effects of infusions from leaves of the Icelandic Angelica archangelica in murine mammary cancer tumours.Water soluble contents of Icelandic Angelica archangelica leaves had suppressing effects on mice injected subcutaneously with Crl-cancer cells. Tumour formation was registered in all mice in the control group. Nine of the eleven mice, which received the infusion, had no tumour formation or developed smaller tumours than the smallest tumour of the control group. These findings have been published in: Sigurdsson S, Ogmundsdottir HM, Hallgrimsson J, and Gudbjarnason S (2005) Antitumour activity of Angelica archangelica leaf extract. In Vivo 19(1):191-4

Bioactive compounds in herbs may show inhibitory effects

Study into the activity of enzyme acetylcholinesterase.

Significant inhibitory effects of herbal extracts on the activity of acetylcholinesterase was found in seeds of the Icelandic Angelica archangelica and in Geranium sylvaticum. The herbs had synergistic or compounding effects, meaning that a mixture of the two was more active than the sum of the two individual constituents. These findings have been published in: Sigurdsson S and Gudbjarnason S (2007) Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum. Z Naturforsch 62c: 689-693

Clinical study on SagaPro

SagaPro was clinically studied in 2011-2012. The product itself was studied - not just its ingredients as is often the case.
 
The study was parallel, randomized, double-blind and placebo-controlled. It is a notable landmark for Icelandic academia and important for the Icelandic natural products industry as a whole, as it is the first study of its kind to be performed on an Icelandic natural product. The project was awarded a grant from the Technology Development Fund in Iceland.
 
The main purpose of the study was to research SagaPro’s efficacy on the frequency of bathroom trips at night due to nocturia in men. The study was approved by both the Icelandic Medicines Agency and the National Bioethics Committee and performed by Encode Ltd.
 
The clinical part of the study was performed by two Icelandic doctors: Hrefna Gudmundsdottir, a specialist in internal medicine and nephrology, and Gudmundur Geirsson, a specialist in urology.
 
Statistically significant results were shown in subgroups of the total study population, such as in those with a small bladder capacity. When the total population was looked at, there was not a statistically significant difference. According to the study, SagaPro is a safe and well-tolerated treatment.
 
Thoughts on significance
 
As previously stated, the study did not yield statistically significant results when the total study population was looked at. We believe the main reason for this to be that the study population was too heterogenous; that is, too diverse. Men with the criteria of having "lower urinary tract symptoms" (LUTS) were tested. LUTS includes many different possible causes for nocturia, so men with many different possible reasons for nocturia were tested.
 
However, when the study data were analyzed there was a clear significance in several subgroups.
 
 
Low bladder volume
More than 3 restroom trips per night
70 years or older - excluding those with sleep disorders (who may go to the restroom because they wake up, as opposed to waking up because they have to go to the restroom).
The information from this study will help us design the next one in such a way that the study population will be more homogenous and the study therefore more focused on specific health problems, as opposed to mainly the resulting symptoms.
 
SagaPro is a clinically studied herbal supplement that reduces urinary frequency in people with low bladder capacity. It´s useful for many groups of people; namely those suffering from bladder problems like an overactive bladder (OAB), sometimes reffered to as "irritable bladder". SagaPro is a proprietary, aqueous extract of Angelica archangelica leaves, harvested from wild plants grown in the pure air and soil of Iceland. Wild Angelica is gathered by local people in an eco- friendly and sustainable manner.  SagaPro supports healthy bladder strength and function both for men and women.
 
Fast acting
* Only 1-2 tablets per day
* Results normally before 1 month
* Calms bladder muscle contraction
* Easy to measure by counting trips to the bathroom
* Improved sleep patterns
 
Clinical results
Participants in a recent clinical trial experienced support for healthy bladder function and reported improved sleep patterns as well.

SagaMedica's peer-reviewed studies

A peer-reviewed article was published in 2012 in The Scandinavian Journal of Urology and Nephrology.

Here you may find a selection of studies, which were performed by our research team and their colleagues. These studies have been published in respected scientific journals.

A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men.Significant results were found in subgroups, such as those with a small bladder capacity. Click here to view the clinical study on SagaPro.

Studies on essential oils of Icelandic Angelica archangelica seeds and Achillea millefolium. Their efficacy regarding the growth of cancer cells. Both cases showed great variability.

Findings regarding Angelica archangelica seeds have been published (along with findings regarding their activity on cancer cells) Considerable activity was found in the essential oils of Icelandic Angelica archangelica. These findings (along with findings regarding the chemical structure of the essential oils in question) have been published in: Sigurdsson S, Ogmundsdottir HM, and Gudbjarnason S (2005) The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L. Anticancer Res 25(3B): 1877-80

Studies on the activity of a tincture (extract with 45% ethanol) from seeds of the Icelandic Angelica archangelica on cancer cells.

Activity of furanocoumarins xanthotoxin and imperatorin was also studied. Findings revealed considerable activity in the tincture and with imperatorin and xanthotoxin (50% reduction in cancer cell proliferation was observed at 2,7 and 3,7 µg/ml). Comparative analysis indicated that activity in the tincture could be solely traced to furanocoumarins. These findings have been published in: Sigurdsson S, Ogmundsdottir HM, and Gudbjarnason S (2004) Antiproliferative effect of Angelica archangelica fruits. Z Naturforsch 59c(7-8):523-7

Research into the effects of infusions from leaves of the Icelandic Angelica archangelica in murine mammary cancer tumours.Water soluble contents of Icelandic Angelica archangelica leaves had suppressing effects on mice injected subcutaneously with Crl-cancer cells. Tumour formation was registered in all mice in the control group. Nine of the eleven mice, which received the infusion, had no tumour formation or developed smaller tumours than the smallest tumour of the control group. These findings have been published in: Sigurdsson S, Ogmundsdottir HM, Hallgrimsson J, and Gudbjarnason S (2005) Antitumour activity of Angelica archangelica leaf extract. In Vivo 19(1):191-4

Bioactive compounds in herbs may show inhibitory effects

Study into the activity of enzyme acetylcholinesterase.

Significant inhibitory effects of herbal extracts on the activity of acetylcholinesterase was found in seeds of the Icelandic Angelica archangelica and in Geranium sylvaticum. The herbs had synergistic or compounding effects, meaning that a mixture of the two was more active than the sum of the two individual constituents. These findings have been published in: Sigurdsson S and Gudbjarnason S (2007) Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum. Z Naturforsch 62c: 689-693

Clinical study on SagaPro

SagaPro was clinically studied in 2011-2012. The product itself was studied - not just its ingredients as is often the case.
 
The study was parallel, randomized, double-blind and placebo-controlled. It is a notable landmark for Icelandic academia and important for the Icelandic natural products industry as a whole, as it is the first study of its kind to be performed on an Icelandic natural product. The project was awarded a grant from the Technology Development Fund in Iceland.
 
The main purpose of the study was to research SagaPro’s efficacy on the frequency of bathroom trips at night due to nocturia in men. The study was approved by both the Icelandic Medicines Agency and the National Bioethics Committee and performed by Encode Ltd.
 
The clinical part of the study was performed by two Icelandic doctors: Hrefna Gudmundsdottir, a specialist in internal medicine and nephrology, and Gudmundur Geirsson, a specialist in urology.
 
Statistically significant results were shown in subgroups of the total study population, such as in those with a small bladder capacity. When the total population was looked at, there was not a statistically significant difference. According to the study, SagaPro is a safe and well-tolerated treatment.
 
Thoughts on significance
 
As previously stated, the study did not yield statistically significant results when the total study population was looked at. We believe the main reason for this to be that the study population was too heterogenous; that is, too diverse. Men with the criteria of having "lower urinary tract symptoms" (LUTS) were tested. LUTS includes many different possible causes for nocturia, so men with many different possible reasons for nocturia were tested.
 
However, when the study data were analyzed there was a clear significance in several subgroups.
 
 
Low bladder volume
More than 3 restroom trips per night
70 years or older - excluding those with sleep disorders (who may go to the restroom because they wake up, as opposed to waking up because they have to go to the restroom).
The information from this study will help us design the next one in such a way that the study population will be more homogenous and the study therefore more focused on specific health problems, as opposed to mainly the resulting symptoms.
 
 
30 tablets
30 days
EUR 27,99
Buy a subscription

Before I started taking SagaPro, frequent urination was a problem for me. This posed significant difficulties for me, both during the day in outdoor activities as well as during the night. SagaPro has helped me a great deal and I now wake fully rested in the morning.

Hjálmar Sveinsson, 67 years old
Now I awake rested